Todd,
Assume you mean from shore. Try fishing the bridge area near the Dorchester Yacht Club off Columbia Blvd. This is the green drawbridge just off the Southeast Expressway on Columbia Blvd. I have not fished this area, but have seen others working this narrow channel area with flies. ASnother spot would be the point opposits this bridge accross the bay where the old naval air station used to be at Squantuim.